Relationship Between Platelet-to-Lymphocyte Count Ratio and Acute Kidney Injury Following Surgery of Stanford Type A Aorta Dissection

Abstract

ObjectiveThe aim of this study was to evaluate the correlation between the hematological index of platelet to lymphocyte ratio (PLR) and the occurrence of acute kidney injury (AKI) following surgery of Stanford acute type A aorta dissection (ATAAD).MethodsWe analyzed the perioperative data of patients with ATAAD who were treated surgically in Fujian Provincial Hospital from December 2016 to December 2021.ResultsPatients were divided into AKI (n = 66) and non-AKI (n = 36) groups based on the Kidney Disease: Improving Global Outcomes (KDIGO). There was no difference in preoperative PLR values (T0 PLR). In addition, the PLR within 24 h (T1 PLR) following surgery was higher in the AKI group than in the non-AKI group (P = 0.001). Reintubation rates, intensive care unit (ICU) stay, and 30-day mortality were significantly different in the AKI group (P = 0.004, P = 0.002 and P = 0.002). Multivariate analyses showed that higher body mass index (BMI) and reduced T1 PLR were the risk factors for postoperative AKI. Receiver operating characteristic (ROC) curve analysis revealed that the decline in the cut-off level of T1 PLR predicted AKI:144.6, the area under the curve (AUC):[95%CI] 0.7146, 0.6112–0.8181, and P = 0.0004, with a sensitivity of 58.33% and a specificity of 77.27%.ConclusionsThis retrospective study demonstrated that a decreased T1 PLR after surgery is a risk factor for the occurrence of postoperative AKI in ATAAD patients and has possible predictive value for AKI.