Abstract
Background/aimWe aimed to evaluate the relationship between YKL-40 and endothelial dysfunction in chronic kidney disease. Materials and methodsTwenty-nine hemodialysis patients, 101 patients with nondialytic (stage 2, 3, 4, and 5 ND) chronic kidney disease (CKD), and 38 healthy individuals as a control group were included. YKL-40 levels were measured by ELISA. Endothelial dysfunction was indirectly measured by flow-mediated dilatation percentage (FMD) in the brachial artery. ResultsYKL-40 levels were higher in CKD patients than controls and highest in HD patients (P = 0.001). FMD values were lower in nondialytic CKD patients and lowest in HD patients (P = 0.001). YKL-40 negatively correlated with eGFR and FMD values (r = –0.674 and r = –0.471, respectively). ConclusionThis study shows that YKL-40 increases with CKD stage and is negatively correlated with FMD measurements.
Highlights
Chronic kidney disease (CKD) is an epidemic that affects 10%–15% of the modern world [1]
YKL-40 levels were higher in CKD patients than controls and highest in HD patients (P = 0.001)
flow-mediated dilatation percentage (FMD) values were lower in nondialytic CKD patients and lowest in HD patients (P = 0.001)
Summary
Chronic kidney disease (CKD) is an epidemic that affects 10%–15% of the modern world [1]. Numerous observational studies have demonstrated increased cardiovascular risk in the setting of CKD. Half of the patients requiring renal replacement treatment die from cardiovascular diseases. Ageadjusted cardiovascular mortality is 15–30 times higher in CKD patients than healthy subjects [1,2]. Traditional cardiovascular risk factors cannot clarify this significant difference. Nontraditional risk factors such as endothelial dysfunction, oxidative stress, and insulin resistance are being investigated. Endothelial dysfunction (ED) is related to cardiovascular disease and progression of CKD and it can be a causative factor for accelerated atherosclerosis in CKD patients [3,4]. ED was previously described as inadequate vasodilatation to certain stimuli. The degree of ED can be measured directly or indirectly
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