Abstract
Plasma triglyceride (TG) concentration and adipose tissue lipoprotein lipase (LPL) activity was determined in male and female rats aged 40 days, 100 days and 1 year. Plasma TG levels increased with age in both sexes, but the rate of rise was greater in female as compared to male rats. As a consequence, plasma TG levels, which were lower in 40 and 100 day old female rats, were similar in both sexes at 1 year. Adipose tissue LPL activity, measured at the same time of day as were plasma TG levels, did not vary as a function of either age or sex. On the other hand, when adipose tissue LPL activity was measured in the early morning, just after rats had finished eating, there was a marked increase in the activity of 40 day old rats of either sex. This dietary-induced rise in adipose tissue LPL activity following eating was not seen in 100 day and 1-year-old rats. Thus, changes in adipose tissue LPL activity cannot account for previously described effects of age and sex on plasma TG concentration.
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