Abstract
ObjectiveTo analyze the relationship between regular physical activity, as assessed by accelerometer and 7-day physical activity recall (PAR), and plasma fibrinogen concentrations.MethodsA cross-sectional study in a previously established cohort of healthy subjects was performed. This study analyzed 1284 subjects who were included in the EVIDENT study (mean age 55.0±13.6 years; 60.90% women). Fibrinogen concentrations were measured in blood plasma. Physical activity was assessed with a 7-day PAR (metabolic equivalents (METs)/hour/week) and GT3X ActiGraph accelerometer (counts/minute) for 7 days.ResultsPhysical exercise, which was evaluated with both an accelerometer (Median: 237.28 counts/minute) and 7-day PAR (Median: 8 METs/hour/week). Physical activity was negatively correlated with plasma fibrinogen concentrations, which was evaluated by counts/min (r = −0.100; p<0.001) and METs/hour/week (r = −0.162; p<0.001). In a multiple linear regression analysis, fibrinogen concentrations of the subjects who performed more physical activity (third tertile of count/minute and METs/hour/week) respect to subjects who performed less (first tertile), maintained statistical significance after adjustments for age and others confounders (β = −0.03; p = 0.046 and β = −0.06; p<0.001, respectively).ConclusionsPhysical activity, as assessed by accelerometer and 7-day PAR, was negatively associated with plasma fibrinogen concentrations. This relation is maintained in subjects who performed more exercise even after adjusting for age and other confounders.
Highlights
Participation in regular physical activity and/or aerobic exercise training is associated with a decrease in all-cause, cardiovascular and cancer mortality [1,2,3] and a reduced risk of fatal and nonfatal coronary events in healthy individuals over a wide age range [4]
The meta-analysis by Kaptoge et al [10], which included 33 studies with 883372 participants, concluded that plasma fibrinogen concentrations were associated with cardiovascular and noncardiovascular mortality, its effects faded when adjusted for other cardiovascular risk factors
We studied 1284 subjects with a mean age of 55.0613.6 years, of which 60.90% were female
Summary
Participation in regular physical activity and/or aerobic exercise training is associated with a decrease in all-cause, cardiovascular and cancer mortality [1,2,3] and a reduced risk of fatal and nonfatal coronary events in healthy individuals over a wide age range [4]. The meta-analysis by Kaptoge et al [10], which included 33 studies with 883372 participants, concluded that plasma fibrinogen concentrations were associated with cardiovascular and noncardiovascular mortality, its effects faded when adjusted for other cardiovascular risk factors. They found that longterm increases in plasma fibrinogen concentrations of 1 g/litre were associated with an approximate doubling of the risk for major cardiovascular disease outcomes. The addition of fibrinogen concentrations to classic risk factors used in assessment scales for cardiovascular risk in people with an intermediate risk can help predict additional events over a 10-year time period [11]
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