Relationship between phase angle and lower-extremity function in older adults: Itabashi Longitudinal Study on Aging

Abstract

ObjectiveEvaluating muscle quality instead of its mass has gained attention in diagnosing sarcopenia. The aim of this study was to examine whether phase angle (PhA) as a bioelectrical impedance analysis (BIA)-derived muscle quality indicator is associated with overall lower extremity function better than appendicular skeletal muscle mass index (ASMI) in community-dwelling older adults. MethodsThis cross-sectional study used data from the Itabashi Longitudinal Study on Aging, a community-based cohort study. A sex-stratified multivariate logistic regression analysis was conducted using PhA and ASMI as exposures, and low physical function defined as short physical performance battery score <10 as the outcome, adjusted for age, being overweight, knee pain, and non-communicable diseases. Discrimination of low physical function was compared using the receiver operating characteristic curve. ResultsThis study included 1464 participants (age 76 [73–80] y; 757 women), with 58 men (8%) and 66 women (9%) exhibiting low physical function. The multivariate odds ratio (OR; 95% confidence interval [CI]) for low physical function among the highest quartile, compared with the lowest quartile were significant in PhA in multiple sites (e.g., OR, 0.09; 95% CI, 0.03–0.32] for men and 0.12; 95% CI, 0.04–0.33 for women in the left leg) but not in ASMI (OR, 0.51; 95% CI, 0.19–1.34 for men and 0.56; 95% CI, 0.21–1.47 for women). Legs and whole-body PhA outperformed the ASMI in discriminating low physical function (P < 0.001). ConclusionPhA reflected physical function better than ASMI; using PhA instead of ASMI in BIA-based morphometric evaluation may add information on low physical function and enhance the diagnostic value of sarcopenia.