Abstract
Considerably enhanced bactericidal activity is achieved by adjusting glutaraldehyde solutions to pH 7.5-8.5 (1–5). In aqueous solution, glutaraldehyde undergoes rapid hydration, the free dialdehyde (I) being in equilibrium with the hydrates II-IV (Scheme I). Using PMR spectroscopy, Hardy et al. (6) studied this equilibrium in D2O solution and reported signals at r 0.28, 4.7, 5.0, 7.4, and 8.3, corresponding to protons a, b, c, d, and e, respectively. On the assumption that there was no free dial- dehyde (I) present in aqueous solution, these authors described the equilibrium by examination of the ratio of the b, c, and d signal integrals after correction to an equivalent number of protons. Their results indicated that the equilibrium was not significantly modified by concentration.
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