Abstract
The relationship between pathologic prognostic factors and abnormal levels of des-γ-carboxy prothrombin and α-fetoprotein was investigated in 42 patients with resectable hepatocellular carcinoma. The frequencies of macroscopic massive type, intrahepatic metastasis, and portal vein tumor thrombus were significantly higher in patients with positive des-γ-carboxy prothrombin (p < 0.05) but not with α-fetoprotein. Other histologic factors in tumorous and nontumorous tissues were not significantly different irrespective of the positivity of these markers. In patients with tumors not more than 6 cm in diameter, the frequency of intrahepatic metastasis was positively correlated with the positivity of des-γ-carboxy prothrombin (p < 0.05) and inversely with that of α-fetoprotein (p < 0.05). Furthermore, intrahepatic metastasis was most frequently observed in patients with positive des-γ-carboxy prothrombin and negative α-fetoprotein (eight of nine) and least frequently in cases with negative des-γ-carboxy prothrombin and positive α-fetoprotein (one of eight). These findings indicated that both des-γ-carboxy prothrombin and α-fetoprotein might be useful markers for the prediction of intrahepatic spread of hepatocellular carcinoma.
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