Abstract
Background: With the heritability of Type 2 diabetes mellitus adding to the disease burden, it would be ideal to find screening tools to detect early changes that could be present in Euglycemic individuals with a genetic predisposition.
 Objective: To study if the parental history of type 2 diabetes mellitus has an association with the time domain, frequency domain and nonlinear basal heart rate variability indices
 Methods and material: Thiscross sectional study was conducted in the Physiology department of Goa Medical college over a period of 2 months on 70 Medical students between the age of 18-21 years, with low-moderate stress (PAS 10) and fair physical activity(PAI of American academy of health and fitness). Using an Inco Polyrite D instrument, data collection was done and the RR interval data was analysed using Kubios software for the basal Heart rate variability indices of time domain, frequency domain and nonlinear methods. Data was entered into Excel spreadsheet and analysed using SPSS version 14. Mann Whitney U test was done to test for statistical significance.
 Result: The mean age of the sample was 18.94± 0.759 years and out of the 70 subjects who had participated in the study 36 (51.4%) subjects had a positive parental family history of type 2 diabetes mellitus while 34 (48.6%) subjects did not. Significant changes were observed in the LF (nu), HF (nu) and LF/HF ratio. A significantly higher LF.n.u (p value - 0,008) and LF/HF (p value- 0.008) was observed in group with family history and a significantly lower HF.n.u ( p value – 0.007)was observed in the same group. No other significant changes were observed in time domain and non linear indices.
 Conclusion: Frequency domain HRV may be useful as a predictive index for diabetes mellitus. The presence of higher sympathetic activity and lower parasympathetic activity in individuals (with comparable stress level, BMI, physical activity) having a positive parental history of diabetes mellitus might indicate an underlying autonomic imbalance
 Keywords: Diabetes, Family history, Heart rate variability, HRV, parental history, Sympathovagal balance
Highlights
An increased risk of type 2 Diabetes mellitus has beenstudied in individuals whose parents have type 2 diabetes mellitus
To study if the parental history of type 2 diabetes mellitus has an association with the time domain, frequency domain and nonlinear basal heart rate variability indices Methods and material: Thiscross sectional study was conducted in the Physiology department of Goa Medical college over a period of 2 months on 70 Medical students between the age of 18-21 years, with low-moderate stress (PAS 10) and fair physical activity(PAI of American academy of health and fitness)
Result: The mean age of the sample was 18.94± 0.759 years and out of the 70 subjects who had participated in the study 36 (51.4%) subjects had a positive parental family history of type 2 diabetes mellitus while 34 (48.6%) subjects did not
Summary
An increased risk of type 2 Diabetes mellitus has beenstudied in individuals whose parents have type 2 diabetes mellitus. Objective: To study if the parental history of type 2 diabetes mellitus has an association with the time domain, frequency domain and nonlinear basal heart rate variability indices Methods and material: Thiscross sectional study was conducted in the Physiology department of Goa Medical college over a period of 2 months on 70 Medical students between the age of 18-21 years, with low-moderate stress (PAS 10) and fair physical activity(PAI of American academy of health and fitness). The presence of higher sympathetic activity and lower parasympathetic activity in individuals (with comparable stress level, BMI, physical activity) having a positive parental history of diabetes mellitus might indicate an underlying autonomic imbalance Keywords: Diabetes, Family history, Heart rate variability, HRV, parental history, Sympathovagal balance
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