Abstract
The aim of the present study was to determine the relationship between p53 gene codon-72 polymorphisms and hypertrophic scar formation following caesarean section (CS). Blood samples from 260 female patients were collected one week following a CS for the detection of p53 gene polymorphisms using a molecular beacon-coupled quantitative polymerase chain reaction technique. Patients had follow-ups for 12–18 months to observe the scar formation. From these observations, the relationship between the p53 codon-72 polymorphisms and hypertrophic scar formation occurrence was investigated. Among the patients with the CCC/CCC genotype, nine patients had hypertrophic scars and 46 patients showed normal healing, which is a ratio of 0.19. However, the follow-up investigations indicated that the presence of a homozygous or heterozygous C-to-G alteration at the codon-72 site in gene p53 resulted in 13 patients with hypertrophic scars and 192 patients with normal healing, which is a ratio of 0.07. Therefore, these results indicate that patients with the CCC/CCC genotype had a higher risk of developing hypertrophic scars compared with that for patients with the CCC/CGC or CGC/CGC genotypes.
Highlights
Abnormal scar formation in wound healing causes aesthetic issues, for female patients
There have been a number of studies investigating the relationship between p53 gene polymorphisms and breast cancer [3,4]
The follow‐up investigations indicated that the presence of a homozygous or heterozygous C‐to‐G alteration at the codon‐72 site in gene p53 resulted in 13 patients with hypertrophic scars and 192 patients with normal healing, which is a ratio of 0.07 (Table I)
Summary
Abnormal scar formation in wound healing causes aesthetic issues, for female patients. There have been a number of studies investigating the relationship between p53 gene polymorphisms and breast cancer [3,4]. Keloid scars, are considered to have specific characteristics that are similar to those of benign dermal fibroproliferative tumors. The p53 mutations in dermal fibroblasts are considered to contribute to the formation of keloids [5,6]. The relationship between p53 polymorphisms and the susceptibility to form hypertrophic scars is an area of interest for a number of researchers [7,8,9]. The aim of the present study was to investigate the relationship between the polymorphisms of p53 codon‐72 and the occurrence of hypertrophic scars for patients receiving a caesarean section (CS)
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