Relationship between oxygen reduction index and early impairment of renal function in patients with obstructive sleep apnea-hypopnea syndrome

Abstract

Objective To explore the relationship between oxygen reduction index (ODI) and early renal impairment in the patients with obstructive sleep apnea-hypopnea syndrome (OSAHS). Methods A total of 187 patients, who were diagnosed as OSAHS by polysomnography (PSG), were divided into three groups according to their ODI (mild: 5≤ODI<15; moderate: 15≤ODI<30; and severe: ODI≥30). The three groups were compared in their serum cystatin C (sCys-C), serum urea nitrogen (BUN), serum creatinine (SCr), serum beta 2-microglobulin (beta 2-MG), superoxide dismutase (SOD) and urinary N-acetyl-beta-D glucosaminide (NAG) and other differences. And the correlation was analyzed between the above-mentioned indexes and their ODIs. Results Significant differences were found in sCys-C, β2-MG, SOD and urinary NAG among the three groups (P<0.05). And ODI was positively correlated with sCys-C, β2-MG and urinary NAG, and negatively correlated with the level of SOD. Conclusion The patients with OSAHS having a high level of ODI often suffer from an early impairment of the renal function. Key words: Obstructive sleep apnea-hypopnea syndrome; Oxygen reduction index; Renal function; Serum cystatin C