Abstract
Summary The in vivo consumption of oxygen and glucose was studied in relation to growth in Walker Carcinoma 256, Hepatoma 5123, and Fibrosarcoma 4956 transplanted in rats. Glucose not eliminated as lactate or carbon dioxide in the efferent blood was presumed to be retained by the tumor. The retention was so high that growth alone could not account for it. As an alternative, the elimination of glucose by the tumors in some unknown manner is suggested. The weight-doubling times of the tumors were independent of oxygen consumption and lactate production. The tumors needed oxygen to survive; there was no indication, however, that in vivo tumor metabolism shifted from respiration to glycolysis when the supply of oxygen was deficient. The opposite was found to be true: glucose consumption and lactate elimination were in direct proportion to the oxygen utilized and a lack of oxygen blocked both of them. The fraction of glucose transformed into lactate was maximal during insulin-induced hypoglycemia. These glucose-starved tumors did not produce lactate during glucose refeeding despite a large glucose utilization. Neither lack of oxygen nor large glucose consumption appeared to be the dominant causes of in vivo lactate production by tumors. Experimental increases in the lactate content of subcutaneous tissue could be obtained in the absence of any tumor. The possibility that glycolysis is related to changes of cellular components not necessarily involved in the neoplastic process is suggested.
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