Relationship Between Ocular Pulse Amplitude and Glaucomatous Central Visual Field Defect in Normal-tension Glaucoma

Abstract

To investigate the relationship between central visual field (VF) defects and ocular pulse amplitude (OPA) in early normal-tension glaucoma (NTG). This retrospective study included 100 eyes of 100 subjects: 54 NTG patients whose mean deviations were better than -7.00 dB and 46 normal subjects. OPA was measured by dynamic contour tonometry. NTG patients were divided into 2 subgroups according to VF tests: the central VF-invading and the central VF-sparing groups. Ocular parameters including OPA, intraocular pressure (IOP), and indices of VF tests were analyzed in glaucoma patients and normal subjects. There was no difference in the OPA between the NTG and normal groups. However, IOP and OPA of the central VF-invading group (14.4 ± 2.87 and 2.9 ± 0.78 mm Hg) were higher than those of the central VF-sparing group (12.7 ± 2.52 and 2.0 ± 0.80 mm Hg; P = 0.025 and P < 0.001, respectively). OPA, but not IOP, showed a positive correlation with the VF test indices that represented central field defects (r = 0.494, P < 0.001). Increased OPA was related to more centrally located VF defects in NTG patients with mild VF defects.