Relationship between obstructive sleep apnea syndrome and cognitive impairment and functional status after stroke

Abstract

Objective:To analyze the correlation between obstructive sleep apnea syndrome (OSAHS) and cognitive impairment and functional status after stroke. Method:From February 2014 to September 2016, a total of 189 patients were included in the study, 33 patients with mild OSAHS were excluded, and finally 86 patients in the study group and 70 patients in the control group were included in the final analysis. The main indicators included the cognitive and functional status. Cognitive status was assessed by nine dimensions: vigilance, attention, memory, working memory, executive, language, insight, mental activity, psychomotor, and intelligence. Functional status was assessed using neurological status and functional independence. Secondary measures included sleepiness, fatigue, anxiety and depression, and sleep quality. Result:The age of the study group was higher than the control group, the BMI was higher than the control group, the average hospitalization time was longer than the control group, and all of the difference were statistically significant (all P<0.05). The total cognitive status of the two groups was significantly different, and the total cognitive status study group was significantly worse than in the control group (t=9.276, P=0.012). In the nine dimensions of cognitive ability, the study group's attention, execution, insight, mental adjustment and intelligence were lower than the control group, and the difference was statistically significant (P<0.05). The functional status of the study group was worse than that of the control group (t=38.094, P=0.000). There were no significant differences between the two groups in terms of sleepiness, fatigue, sleep quality, anxiety and depression (P>0.05). Conclusion:The cognitive impairment and functional status of stroke patients with OSAHS are significantly worse. OSAHS is a risk factor for poor prognosis in stroke patients.