Relationship between obesity-related markers, biochemical metabolic parameters, hormonal profiles and sperm parameters among men attending an infertility clinic.

Abstract

Obesity causes many health problems as well as has negative effects on fertility. However, little is known about the association between obesity-related markers (hip circumference (HC), waist circumference (WC), waist to hip ratio (WHR), waist to height ratio (WHtR), body fat mass (BFM), skeletal muscle (SM), resting metabolism (RM), visceral fat (VF), and visceral adiposity index (VAI)) and sperm parameters. This cross-sectional study was conducted on 98 men in three groups: normal-weight (Nw; body mass index: BMI < 25 kg/m2 ), overweight (Ow; BMI: 25-29 kg/m2 ), and obese (Ob; BMI: 30-35 kg/m2 ) to investigate this issue. The mean WC, HC, WHtR, BFM, SM, RM, and VF were remarkably higher (p< 0.001) for subjects in the Ob group than in Ow and Nw. In Nw, positive correlations were observed between BFM (r= 0.402) and VAI (r= 0.353) and sperm progressive motility (p< 0.05). In Ob males, there was a positive correlation (r= 0.430) between sperm progressive motility and height and a negative relation (r= -0.447) between sperm progressive motility and WHtR. We found the association between serum testosterone (T) levels, T/estradiol ratios, and semen parameters being dependent on obesity-related markers which confirms the negative effects of obesity on male hormones. In conclusion, WHtR is a valuable parameter in infertility clinics that warrants further studies.