Abstract
Introduction: Characterized by excess adipose tissue mass and body fat distribution may have a negative impact on health of a people and their wellbeing. . Prevalence of obesity has drastically increased in last three decades which has been found to reduce the life expectancy and overall quality of life. One among six adults all over the world and nearly 2.8 million individuals die every year due to obesity or being overweight according to the WHO. There is a huge burden of cost associated with obesity in health care system due to long term consequences of the disease. Calcium stimulates the activity and expression of fatty acid synthaze which is a key enzyme in novo lipogenesis and inhibits lipolysis in calcium dependent trend. Various important functions such as neuronal activity, muscle contraction, aggregation of platelets, and resistance of insulin, cellular death and hypertension are mediated by intracellular calcium. Thus increase in concentration of intracellular calcium adipose tissues promotes storage of triglycerides in adipocytes by exerting a control of lipogenesis and lipolysis in coordination.
 Material & Methods: This cross-sectional study was conducted at K.M. Medical College and Hospital Matura UP. The study was done on 100 subjects with same number of healthy matched controls. Those patients with pre-existing disease such as cardiovascular disease, diabetes mellitus, hypertension, endocrine disorders, renal diseases, smoking, subjects on oral vitamin D or calcium supplementation or family history of obesity or postmenopausal women, pregnant females were excluded from the study.
 Results: It is observed that the serum calcium levels were significantly high in cases i.e. obese subjects compared to non-obese controls. Correlation of serum calcium with BMI was 0.65 while with waist to hip ratio it was found to be 0.51 among cases. In controls the correlation of BMI and serum calcium was observed to be 0.32 whereas it was 0.21 with waist to hip ratio.
 Conclusion: From present study it can be noted that serum calcium is positively correlated with BMI and waist to Hip ratio and are increased in obese people. This supports the assertion that calcium may have a fundamental role in risk of development of obesity and obesity may have an impact on calcium metabolism which leads to hypercalcemia.
Highlights
Characterized by excess adipose tissue mass and body fat distribution may have a negative impact on health of a people and their wellbeing
It is observed that the serum calcium levels were significantly high in cases i.e. obese subjects compared to nonobese controls
From present study it can be noted that serum calcium is positively correlated with Body Mass Index (BMI) and waist to Hip ratio and are increased in obese people
Summary
Characterized by excess adipose tissue mass and body fat distribution may have a negative impact on health of a people and their wellbeing. Calcium stimulates the activity and expression of fatty acid synthaze which is a key enzyme in novo lipogenesis and inhibits lipolysis in calcium dependent trend. Various important functions such as neuronal activity, muscle contraction, aggregation of platelets, and resistance of insulin, cellular death and hypertension are mediated by intracellular calcium. Increase in concentration of intracellular calcium adipose tissues promotes storage of triglycerides in adipocytes by exerting a control of lipogenesis and lipolysis in coordination
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
More From: International Journal of Medical and Biomedical Studies
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.