Relationship Between Nonalcoholic Fatty Liver and Non High Density Lipoprotein to High Density Lipoprotein Ratio

Abstract

Aim: The aim of this study was to investigate the relationship between non-alcoholic fatty liver and demographic characteristics, laboratory parameters and predictory non-high density lipoprotein to high density lipoprotein ratio. Material and Methods: Between February and September 2020, 329 patients with fatty liver prediagnosis were evaluated prospectively. Laboratory (whole blood counts, transaminases, lipid profiles, 25-oh vitamin d3 levels) and ultrasonography findings, body height, body weight and body mass index of patients were compared between fatty liver and control groups. Results: Fatty liver was diagnosed in 164 patients out of 329 participants. There were significant relationships between existence of fatty liver and age, body weight, body mass index, triglyceride levels, non-high density lipoprotein, non-high density lipoprotein to high density lipoprotein ratios. Also relationships between severity of fatty liver and body weight, alanine aminotransferase and body mass index were found to be significant. There were no relationship between existence of fatty liver and monocyte to high density lipoprotein ratio and vitamin D levels. Linear regression analysis for Non-HDL/ HDL ratio in diagnosis of nonalcoholic fatty liver, revealed a correlation coefficient as r=0.179. Positive and negative predictive values for Non-HDL/HDL ratio in diagnosis of nonalcoholic fatty liver were, 56.3% and 60.9%, respectively . Conclusion: There is a significant relationship between fatty liver and non-high density lipoprotein to high density lipoprotein ratio. This ratio may be a simple and readily available predictor in patients with fatty liver.