Abstract
BackgroundNon-fasting triglycerides (TG) are considered a better predictor of cardiovascular disease (CVD) than fasting TG. However, the effect of non-fasting TG on fatal CVD events remains unclear. In the present study, we aimed to explore the relationship between non-fasting TG and CVD mortality in a Japanese general population.MethodsA total of 6,831 participants without a history of CVD, in which those who had a blood sampling over 8 hours or more after a meal were excluded, were followed for 18.0 years. We divided participants into seven groups according to non-fasting TG levels: ≤59 mg/dL, 60–89 mg/dL, 90–119 mg/dL, 120–149 mg/dL, 150–179 mg/dL, 180–209 mg/dL, and ≥210 mg/dL, and estimated the multivariable-adjusted hazard ratios (HRs) of each TG group for CVD mortality after adjusting for potential confounders, including high density lipoprotein cholesterol. Additionally, we performed analysis stratified by age <65 and ≥65 years.ResultsDuring the follow-up period, 433 deaths due to CVD were detected. Compared with a non-fasting TG of 150–179 mg/dL, non-fasting TG ≥210 mg/dL was significantly associated with increased risk for CVD mortality (HR 1.56: 95% CI, 1.01–2.41). Additionally, lower levels of non-fasting TG were also significantly associated with increased risk for fatal CVD. In participants aged ≥65 years, lower levels of non-fasting TG had a stronger impact on increased risk for CVD mortality, while higher levels of non-fasting TG had a stronger impact in those aged <65 years.ConclusionIn a general Japanese population, we observed a U-shaped association between non-fasting TG and fatal CVD events.
Highlights
Compared with a non-fasting TG of 150–179 mg= dL, non-fasting TG ≥210 mg=dL was significantly associated with increased risk for cardiovascular disease (CVD) mortality among men (HR 2.38; 95% Confidence intervals (CIs), 1.14–4.94) and all participants combined (HR 1.56; 95% CI, 1.01–2.41), but not among women (HR 1.20; 95% CI, 0.68–2.14)
The present study showed that a nonfasting TG ≥210 mg=dL significantly increased risk for CVD mortality compared with a non-fasting TG of 150–179 mg=dL, which was associated with the lowest risk
We found a weaker association between non-fasting TG levels and CVD mortality among women compared with men, while there was no significant interaction between non-fasting TG and sex for CVD mortality
Summary
TG levels gradually increase after a meal, taking 8 to 10 hours to reach a fasting state.[7] Because we eat regularly during the day, the body spends most of its time in the non-fasting state. Non-fasting triglycerides (TG) are considered a better predictor of cardiovascular disease (CVD) than fasting TG. The effect of non-fasting TG on fatal CVD events remains unclear. We aimed to explore the relationship between non-fasting TG and CVD mortality in a Japanese general population
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