Relationship Between Non-Alcoholic Fatty Liver, Intestine, And Microbioata

Abstract

Non-alcoholic fatty liver disease (NAFLD) is a serious disease that can contribute to liver cancer and death associated with liver diseases. There is a close relationship between the liver and the intestine via the portal vein, and gut microbiota plays a role in the pathogenesis of NAFLD. As a result of increased intestinal permeability and endotoxin transmission due to bacterial overgrowth in the intestine, the production of proinflammatory cytokines and chemokines in the liver increases. It triggers fatty liver. In this mini-review, we will describe the relationship between NAFLD, intestine, and microbiota.