Relationship between myocardial reperfusion and intracoronary aspiration ingredients in patients with acute myocardial infarction undergone primary percutaneous coronary intervention

Abstract

Objective To study the relationship between myocardial reperfusion and intracoronary aspiration ingredients in patients with acute ST- segment elevation myocardial infarction(STEMI) undergone primary percutaneous coronary intervention (PCI). Methods Aspiration catheter was used in 150 consecutive patients(96 males and 54 females)with STEMI undergoing primary PCI. Filtered, aspirated materials were fixed in formalin for 24 hours. Histological sections were prepared and stained with hematoxylin and eosin for examination. According to the pathological findings, patients were divided into 3 groups: thrombus group, plaque group and mixed group. Clinical data and myocardial reperfusion were analyzed and compared among the three groups. Results Aspiration catheter was successfully reached the lesion in 97.3% (146/150) of the patients, and no materials obtained in 15 cases. Effective thrombus aspiration was done in 87.33% (131 of 150) of the patients. The rates of coronary flow less than TMP class 3 in criminal vessel were 43.86% (25/57), 14.81% (4/27) and 17.02% (8/47) in thrombus group, plaque group and mixed group, respectively. Multivariate and non-conditional Logistic analysis showed that plaque components were closely related with the level of myocardial reperfusion after primary PCI (OR: 3.412, P=0.011). Conclusions Intracoronary aspiration plays an important role in improving myocardial reperfusion in patients with STEMI undergone primary PCI. Key words: Acute myocardial infarction; No-reflow; Catheter; Plaque; Thrombus