Relationship Between Morning Hypertension and T-Peak to T-End Interval in Patients with Suspected Coronary Heart Disease

Abstract

Objective: To investigate the relationship between morning hypertension (MH) and T-peak to T-end interval (Tp-e interval) in patients with suspected coronary heart disease. Methods: Patients with typical symptoms of coronary heart disease were examined by ambulatory blood monitoring, electrocardiogram, echocardiography, and coronary angiography, and were assigned to two groups on the basis of blood pressure: an MH group and a morning normotension (MN) group. The following data were collected and compared: basic characteristic, Tp-e interval, corrected QT (QTc) interval, echocardiography parameters, and Gensini score of the two groups. Results: Three hundred fifty-eight patients, with a mean age of 64 years (54.1% men), were divided into the MH group (n=170) and the MN group (n=188). Tp-e interval (84.52±14.77 ms vs. 65.19±19.03 ms, P<0.001), QTc interval (416.21±29.59 ms vs. 401.70±36.10 ms, P<0.001), left ventricular mass index (121.42±10.97 g/m2 vs. 105.63±17.10 g/m2, P<0.001), and Gensini score (72.12±32.90 vs. 39.47±29.32, P<0.001) were significantly increased in the MH group compared with the MN group. Morning systolic blood pressure (r=0.678, P<0.001), morning diastolic blood pressure (r=0.404, P<0.001), Gensini score (r=0.513, P<0.001), and left ventricular mass index (r=0.646, P<0.001) were correlated with Tp-e interval. Conclusion: Tp-e interval is correlated with morning systolic blood pressure and diastolic blood pressure in patients with coronary heart disease. More research on how the Tp-e interval changes after control of MH is necessary.