Abstract
Many studies have researched the mitochondrial DNA (mtDNA) A10398G in Parkinson's disease (PD) to determine the association between mtDNA A10398G and PD, but the results of their research were not consistent. Therefore, we performed a meta-analysis to demonstrate the connection between mtDNA A10398G and the susceptibility of PD. We searched PubMed, Web of Science, Springer Link, EMBASE and EBSCO databases up to identify relevant studies. Through strict inclusion and exclusion criteria, at last, 9 studies (total 3381 cases and 2810 controls) were included in our meta-analysis. We used the STATA 12.0 statistics software to calculate the pooled odds ratios (ORs) and 95% confidence intervals (CIs) to evaluate the genetic association between mtDNA A10398G and the risk of PD. We performed subgroup analysis to clarify the possible roles of the mtDNA A10398G polymorphism in the aetiology of PD in different ethnicities. Our meta-analysis indicates that although there was no significant association between mtDNA A10398G and PD in the Asian population (G vs. A: OR = 1.090, 95% CI = 0.939–1.284, P = 0.242), in the Caucasian population the G allele of mtDNA A10398G mutations may be a potential protective factor of PD (G vs. A: OR = 0.699, 95% CI = 0.546–0.895, P = 0.005). Further well-designed studies with larger samples are needed to validate these results.
Highlights
Parkinson’s disease (PD), characterized by resting tremor, rigidity, slowness of movements and postural instability, is the second most common neurodegenerative disorder after Alzheimer’s disease [1]
Our meta-analysis indicates that there was no significant association between mitochondrial DNA (mtDNA) A10398G and PD in the Asian population (G vs. A: odds ratios (ORs) = 1.090, 95% confidence intervals (CIs) = 0.939–1.284, P = 0.242), in the Caucasian population the G allele of mtDNA A10398G mutations may be a potential protective factor of PD (G vs. A: OR = 0.699, 95% CI = 0.546–0.895, P = 0.005)
We all know that the aetiological factor of PD is still obscure, the genetic factor has been well confirmed to have a great contribution to the development of PD
Summary
Parkinson’s disease (PD), characterized by resting tremor, rigidity, slowness of movements and postural instability, is the second most common neurodegenerative disorder after Alzheimer’s disease [1]. Mutations in a number of mitochondrial related genes, such as PARK6, PARK2, 12SrRNA, PINK1, POLG and DJ, have been confirmed to be associated with PD [3, 4]. Among these genes, 12SrRNA was located in mitochondrial and the others were located in the nucleus. These genes participate in the coding of mitochondrial proteins required to build mitochondria and maintain the function of mitochondria [5]
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