Abstract
To present the efficacy and safety of Metronidazole and co-trimoxazole in the treatment of diarrhea ca used by Entamoeba histolytica, cyst and trophozyed in pa tients presented to the emergency department and emergency pediatric clinic in Queen Alia Hospital ( Jordan). A strategy for diagnosis Entamoeba histoly tica was evaluated by studying 181 patients aged 2-50 ye ars. Between the 1st of May 2009 and the beginning of May 2010, 181 patients with intestinal amoebiasis w ere recruited for this study from the Emergency Department and emergency Pediatric Clinic at Queen Alia Military Hospital. After doing stool analysis for every patient, Metronidazole 500 mg three times was given to the adult group and 40 mg kg -1 day in three divided doses for the pediatric group for 10 days a nd two tablets twice daily for adults and 5 mL twic e daily for children for ten days of co-trimaxazole, with f ollow up stool analysis after one week of treatment . Out of 181 patients (81) patients were adult’s age (14-50 years) and (100 patients) were children aged (2-14 years). About 5.5% of the patient showed the amoebic trophozoite in their stool while the remaining showed onl y the amoebic cysts. Over all metronidazole and co-tr imoxazole produced a clinical response rate of 95% in both adults and children group after 10 days course of Metronidazole. Our findings demonstrated the efficacy of 10 day of course Metronidazole and co-t rimoxazole in eradication intestinal amoebiasis for which the causative organism is identified by simpl e stool examination.
Highlights
Enteric protozoan infections are among the most passage of bloody mucoid stool (Schuster and Ramirezcommon infections in human’s worldwide and Avila, 2008; Lourenssen et al, 2010)
The clinical picture of amoebic colitis is characterized by abdominal pain, cramps, generalized, weakness, tenesmus and passage of blood and mucus in the stool (Anand et al, 1997)
The study protocol was designed with reference to guidelines proposed for the evaluation of Metronidazole and Septrin for the treatment of amoebic colitis
Summary
Enteric protozoan infections are among the most passage of bloody mucoid stool (Schuster and Ramirezcommon infections in human’s worldwide and Avila, 2008; Lourenssen et al, 2010). Amoebiasis (Amoebic dysentery) is an infectious varies between 1% in developed countries to 50-80% in tropical countries where transmission of E. histolytica cyst from human by untreated drinking water is common. Mohammed Aladwan et al / American Journal of Microbiology 3 (2): 31-33, 2012 with E. histolytica cyst from human faeces and direct faecal oral contract are the commonest means of infection (Kreidl et al, 1999). About 10% of patients infected have clinical symptoms, 8098% with amoebic colitis, 2-0% with extra-intestinal disease (liver abscess). The clinical picture of amoebic colitis is characterized by abdominal pain, cramps, generalized, weakness, tenesmus and passage of blood and mucus in the stool (Anand et al, 1997). In areas endemic for E. histolytica infection, these symptoms are often diagnosed as non-dysenteric intestinal amoebiasis and irritable bowel syndrome is not distinct (Schuster, 1993)
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
