RELATIONSHIP BETWEEN METALLOPROTEINASE AND TIMP1 EXPRESSION AND INTENSITY OF CERVICAL INFLAMMATORY REACTION IN WOMEN OF DIFFERENT AGE GROUPS WITH CERVICAL INTRAEPITHELIAL NEOPLASIA AND MICROINVASIVE CARCINOMA

Abstract

Objective : to study the relationship between metalloproteinases and expression TIMP1 expression and intensity of inflammatory response in the cervical stroma of women with cervical intraepithelial neoplasia and microinvasive carcinoma. M at erial and methods . Morphological, morphometric and immunohistochemical examination of cervical biopsies in patients with cervical epithelial neoplasia (cINI–III) and microinvasive carcinoma was carried out. all patients were divided into two age groups: group 1 consisted of 95 patients of early reproductive age ranged from 18 to 35 years (mean age 28.5 ± 0.58 years) and group 2 consisted of 85 perimenopausal and menopausal patients aged 49 to 65 (mean age 55.4 ± 0.98 years). Results . In women of both age groups, the density of inflammatory cell infiltrate was shown to increase, being significantly higher in women of group 1 than in women of group 2. the increase in the expression level of metalloproteinases-2, -3, -7, and -9 with dysplasia progression was observed in women of both age groups, being also higher in group 1 women. the tIMP1 expression level was higher in group 2 women and increased with disease progression. Conclusion . In young women, pronounced and active inflammation in the cervical stroma contributes to a high potential for metalloproteinase synthesis. a higher level of tIMP1 expression in perimenopausal and menopausal women may be one of the factors contributing to a decrease in the metalloproteinase synthesis in these women.