Relationship Between Metabolic Scores, Systemic Inflammation, Renal Function, and High-risk Peripheral Arterial Disease

Abstract

Summary Background Metabolic syndrome (MS) associated with systemic inflammation identifies high-risk cardiovascular diseases (CVDs). Deteriorated renal function leads to poor cardiovascular outcomes. However, the relationship between such metabolic anomaly, systemic inflammation and renal function in patients diagnosed with peripheral arterial disease (PAD) remains largely unknown. Materials and methods A total of 249 consecutive individuals meeting the study criteria from our outpatient clinics were enrolled in the study. Baseline demographic data and information regarding metabolic abnormalities [presented as Adult Treatment Panel (ATP) III scores], high-sensitivity C-reactive protein (Hs-CRP) level, and estimated renal function [calculated by the Modification of Diet in Renal Disease (MDRD) method] were obtained. High-risk PAD was defined by utilizing the ankle–brachial index (ABI) method. Results Of all 249 subjects, 60 had diagnostic high-risk PAD. The prevalence of PAD increased in a significant trend with worsening ATP III scores. By utilizing a multivariate adjustment model, body mass index and worse renal function were independently associated with PAD (both p p Conclusion The combination of metabolic scores and systemic inflammation in terms of Hs-CRP superimposed on estimated renal function yielded better identification of patients at high risk for PAD. Our data suggested that early recognition of PAD may be enhanced in a population by screening for established higher cardiovascular risks combined with abnormal renal function.