Relationship between melatonin receptor 1B (rs10830963 and rs1387153) with gestational diabetes mellitus: a case-control study and meta-analysis.

Abstract

Variants rs10830963 (C/G) and rs1387153 (C/T) in MTNR1B have been shown with an increased risk of developing type 2 diabetes and gestational diabetes mellitus. However, the results are still controversial, and evidence was not satisfied. Hence, a case-control study and a further meta-analysis will be performed in this study. We recruited 674 GDM patients and 690 controls from Jan 2010 and Jan 2014. The SNPs were genotyped by ABI TaqMan SNP Genotyping Assays. MTNR1B rs10830963 and rs1387153 single nucleotide polymorphisms (SNPs) were performed for association analysis. Then a systematic search of all relevant studies was conducted. A meta-analysis was performed to prove the relationship between melatonin receptor 1B (rs10830963 and rs1387153) with GDM. The case-control study presented that G allele of the rs10830963 and T allele of rs1387153 were significantly associated with increased risk of GDM. The further meta-analysis included other five studies showed that the frequency of MTNR1B rs10830963 G allele and rs1387153 T allele are higher in GDM patients. The case-control study proved that the risk allele (G allele) of rs10830963 and (T allele) of rs1387153 lead to a higher risk for GDM. The further meta-analysis provides additional evidence supporting the above results. Due to the limited data currently available in different race population, further studies with large sample sizes are required.