Relationship between Mammographic Density and IGF Levels Among Hispanic and Non-Hispanic White Women

Abstract

Abstract : The purpose of this study is to investigate the relationship between breast density and IGF levels in pre and postmenopausal Hispanic and non-Hispanic White women. This study will use data collected from the parent study, the Women's Breast and Bone Density (WBBD) Study, in combination with the results from laboratory analyses to test this association. The parent study was completed on May 31, 2003. Recruitment was lower than expected for the Hispanic women, but recruitment goals were met or exceeded for the non-Hispanic White women. The total numbers are: 60 premenopausal Hispanic women, %5 premenopausal non- Hispanic White women, 28 postmenopausal Hispanic women, and %8 postmenopausal White women. The serum and plasma samples have been collected for the Insulin-like Growth Factors (IGFs) and their binding proteins (IGFBPs) assays used in this study (including TGF-1, IGFBP-3, and Free IGF-1), however, the assays will be completed in Fall 2003. The mammographic density measurements are currently being finalized and will be merged with the data collected from questionnaires, physical measurements, and dual energy x-ray absorptiometry (DXA) scans. When the laboratory analyses are complete, the results of those tests will be merged with the WBBD data so the analysis can be completed and results disseminated.