Relationship between location, size, morphology and histopathological types of neoplastic colorectal polyps

Abstract

Objective: To evaluate correlations between location, size, morphology and histopathological types of neoplastic colorectal polyps. Subject and method: We reviewed endoscopic and histopathologic data from 215 patients undergoing colonoscopy. We categorized colorectal polyps according to anatomic location, size, and morphology. Histopathological features were classified using the World Health Organization (WHO-2019) classification. Result: Neoplastic polyps were mostly located in the left colon and rectum. Serrated polyps with dysplasia were not found in right colon. The proportion of colonic polyp with a size larger than 1cm and those with a size smaller or equal 1cm accounted for 85.1% and 14.9%, respectively. The cancer risk of polyps larger than 1cm were higher than those of polyps smaller or equal 1cm. Villous adenoma and serrated polyp with dysplasia were found exclusively in polyps bigger than 1cm (p<0.001). The proportions of sessile adenoma and pedunculated adenoma accounted for 41.9% and 58.1%, respectively. The existence of polyps stalk had no relationship with histopathological types (p=0.127). The cancer risk of villous adenoma was higher than those of other histopathological types (OR = 4.6, 95% CI = 1.9 - 11.3, p<0.001). Conclusion: The localization of polyp was mostly in left colon and rectum. Polyp size larger than 1cm and villous adenoma type were closely related to the malignant change in neoplastic polyps.