Relationship between local gyrification index and age, intelligence quotient, symptom severity with Autism Spectrum Disorder: A large-scale MRI study

Abstract

Gyrification is one of the most important characteristics in the cerebral cortex and the local gyrification index (LGI) was used to quantify the regional changes in gyrification. The aim of this study was to evaluate LGI alterations in autism spectrum disorder (ASD) individuals in comparison with typically developing (TD) controls and the association of the LGI with age, intelligence quotient (IQ), and symptom severity in a large multicenter dataset. Structural MRI datasets selected from Autism Brain Imaging Data Exchange I and II (ABIDE I and ABIDE II) repository (606 ASD individuals and 765 age-matched TD controls) were used to calculate LGI values. The correlation between the LGI and age, IQ, and other clinical measurements were assessed. No differences in LGI were found between ASD individuals and TD controls after FDR multiple comparison correction, however, LGI decreased with age in both ASD and TD groups. In the TD group, a significant positive correlation was found between the LGI and full IQ (FIQ) in the parahippocampal gyrus, parsopercularis of left hemisphere and entorhinal cortex, parahippocampal, superior temporal gyrus of right hemisphere, but was not observed in the ASD group. Furthermore, a positive correlation between the LGI and Autism Diagnostic Interview-Revised (ADI-R) Repetitive and Restrictive Behaviors (RRB) score was found in the left inferior parietal lobule, lateral occipital cortex, superior frontal gyrus and right superior frontal gyrus, inferior temporal gyrus. In summary, these results demonstrate that the ASD is a truly heterogeneous neurodevelopmental disorder. Future investigations are required that group ASD patients into more homogeneous subtypes.