Abstract
Glycosylated hemoglobin (HbA1c) was the best indicator of glycemic control, which did not show the dynamic relationship between glycemic control and lipid profiles. In order to guide the health management of Type 2 diabetes (T2D), we assessed the levels of lipid profiles and fasting plasma glucose (FPG) and displayed the relationship between FPG control and lipid profiles. We conducted a cross-sectional study that included 5822 participants. Descriptive statistics were conducted according to gender and glycemic status respectively. Comparisons for the control of lipid profiles were conducted according to glycemic control. Four logistic regression models were generated to analyze the relationship between lipid profiles and glycemic control according to different confounding factors. The metabolic control percentage of FPG, triglyceride (TG), total cholesterol (TC), high density lipoprotein cholesterol (HDL-C) and low density lipoprotein cholesterol (LDL-C) was 27.50%, 73.10%, 28.10%, 64.20% and 44.80% respectively. In the fourth model with the most confounding factors, the odds ratios (ORs) and 95% confidence intervals (CIs) of TG, TC, LDL-C and HDL-C were 0.989 (0.935, 1.046), 0.862 (0.823, 0.903), 0.987 (0.920, 1.060) and 2.173 (1.761, 2.683). TC and HDL-C were statistically significant, and TG and LDL-C were not statistically significant with adjustment for different confounding factors. In conclusion, FPG was significantly associated with HDL and TC and was not associated with LDL and TG. Our findings suggested that TC and HDL should be focused on in the process of T2D health management.
Highlights
The primary task of health management in Type 2 diabetes (T2D) patients is to prevent diabetes-related complications
Lipid profiles referred to lipids in plasma, generally including triglyceride (TG), total cholesterol (TC), high density lipoprotein (HDL), and low density lipoprotein (LDL) clinically [3]
All these results showed that poor control of blood glucose and lipid profiles in T2D patients was a problem to be solved [24,25]
Summary
The primary task of health management in Type 2 diabetes (T2D) patients is to prevent diabetes-related complications. Previous studies have shown that good control of lipid profiles and glycemic levels can effectively prevent complications such as cardiovascular disease, diabetic nephropathy and diabetic retinopathy [1,2]. Lipid profiles referred to lipids in plasma, generally including triglyceride (TG), total cholesterol (TC), high density lipoprotein (HDL), and low density lipoprotein (LDL) clinically [3]. For patients with cardiovascular disease and T2D, lipid profiles should be strictly controlled to reduce mortality and complications [4]. Association guidelines, glycemic control needed to be determined based on levels of self-monitoring of blood glucose (SMBG) and glycosylated hemoglobin (HbA1c). As a gold standard for evaluating long-term glycemic control, HbA1c < 7.0 was clinically defined as glycemic control [5].
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