Abstract
This study investigated the impact of folic acid (FA) fortification on global DNA methylation and its relationship with RBC folate in the WHI‐OS. We selected ~400 postmenopausal women (50–79 y) from the highest (891 ± 210 ng/mL, mean ± SD; n=206) and lowest (350 ± 79 ng/mL; n=202) tertiles of RBC folate distribution matching on age and time of blood draw: pre, peri, or post‐FA fortification. Global DNA methylation was measured in blood leukocytes collected at study baseline using liquid chromatography‐mass spectrometry. No differences (P=0.86) in DNA methylation were detected between the pre (5.04 ± 0.4%), peri (5.05 ± 0.4%), or post (5.03 ± 0.4%) FA periods (1‐way ANOVA). However, methylation was lower (4.9 vs. 5.2%; P =0.01) in the highest (859 ± 188 ng/mL, n=53) vs. the lowest (371 ± 88 ng/mL, n=29) RBC folate tertile in the post‐FA period (t‐test). Additional analyses are underway to explore possible interactions between FA fortification and RBC folate on global DNA methylation among postmenopausal women.Funded by NIH R01 CA120523, N01WH22110, HHSN26820110
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