Relationship between laryngopharyngeal reflux and calcification of arytenoid cartilage in male patients with idiopathic laryngeal contact granuloma

Abstract

Objective:To investigate the relationship between laryngopharyngeal reflux and arytenoid cartilage calcification in male idiopathic laryngeal contact granuloma. Method:The clinical data of 92 male patients with idiopathic laryngeal contact granuloma who had the thin laryngeal CT scan images and laryngeal reflux symptom index（RSI） scale data before treatment were analyzed retrospectively. The effect of laryngopharyngeal reflux on the calcification of arytenoid cartilage in laryngeal contact granuloma patients was analyzed by Chi-square statistics with SPSS 16.0 software. Result:Among the 92 patients, 44 patients with RSI>13（47.83%） and 48 patients with RSI≤13（52.17%）. Unilateral granuloma was found in 87 cases（94.57%） and bilateral granuloma in 5 cases（5.43%）. A total of 97 sides of the diseased side, there were 87 sides of arytenoid cartilage with calcification（89.69%） and 10 sides without calcification（10.31%）. Among the patients with RSI>13, there were 45 sides of arytenoid cartilage with calcification（45/46, 97.83%） and one side without calcification（1/46, 2.17%）, and in the patients with RSI≤13, there were 42 sides of arytenoid cartilage with calcification（42/51, 82.35%） and 9 sides without calcification（9/51, 17.65%）. The calcification rate of arytenoid cartilage in patients with RSI>13 group was significantly higher than that in RSI≤13 group（χ²=4.701, P=0.030）. Conclusion:The calcification rate of arytenoid cartilage in male idiopathic laryngeal contact granuloma patients with laryngopharyngeal reflux is higher than that in patients without laryngopharyngeal reflux. Laryngopharyngeal reflux may aggravate or promote the inflammatory reaction of granuloma and accelerate the calcification of arytenoid cartilage.