Relationship between intraocular pressure, anterior chamber depth and lens thickness in primary open-angle glaucoma patients.

Abstract

To investigate the relationship between intraocular pressure (IOP), anterior chamber depth (ACD) and lens thickness (LT) in primary open-angle glaucoma (POAG) patients and compare with age- and sex-matched controls. A cross-sectional analytical study of 62 newly diagnosed POAG patients compared with 62 age- and sex-matched control subjects in a tertiary eye clinic. Socio-demographic data and ocular examinations were documented. IOP was measured using the Goldmann applanation tonometer. LT and ACD were measured using A-scan ultrasonography and the IOLMaster, respectively. Data were analyzed using SPSS version 19.0 and level of significance set at p value <0.05. In the glaucoma group and control groups, respectively, mean age was 60.3±8.9 and 58.5±8.1years (p=0.234), mean IOP was 28.27±7.88 and 14.47±2.60mmHg (p<0.001), mean ACD was 3.12±0.27 and 3.15±0.24mm (p=0.514), mean LT was 4.24±0.46 and 4.23±0.45mm (p=0.903), and mean ACD was shallower in females (p=0.034) and (p=0.001). In the glaucoma group, there was a positive correlation between IOP and ACD (r=0.022, p=0.864), but a negative correlation between IOP and LT (r=-0.04, p=0.758) and ACD and LT (r=-0.058, p=0.657). In the control group, there was a positive correlation between IOP and ACD (r=0.141, p=0.275), IOP and LT (r=0.031, p=0.811) and ACD and LT (r=0.016, p=0.901). ACD is shallower in females. There is no significant correlation between IOP and ACD or between IOP and LT in POAG as well as normal individuals.