Abstract
The pathogenesis of type 1 diabetes are relates to genetic factors,environmental factors and autoimmune factors.Based on genetic factors and triggered by environmental factors,it is an autoimmune disease characterized by T lymphocytes-mediated progressive damage of islet β cells.As one of environmental factors,intestinal flora has a direct relationship with the occurrence of type 1 diabetes,by changing intestinal permeability and host immune system.There exist interactions among intestinal flora,host intestinal immune and type 1 diabetes.Studying on intestinal flora may provide clues for prevention and treatment of type 1 diabetes. Key words: Intestinal flora; Intestinal permeability; Intestinal immune; Type 1 diabetes mellitus
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