Abstract
Objective To investigate the relationship between serum phospholipid polyunsaturated fatty acids (PUFA) and interleukin-6 (IL-6) in patients with metabolic syndrome. Methods Serum phospholipid PUFA profiles of 61 patients with metabolic syndrome and 55 healthy controls was analyzed with high performance gas chromatography. Enzyme-linked immunosorbent assay was used to measure serum IL-6 levels. Results The IL-6 concentration was significantly higher in the MS group than in the control group [(16.0±4.7)pg/ml vs. (9.2±2.6)pg/ml, P=0.000]. The total PUFA percentage was lower in the MS group than in the control group [(47.2±2.4)% vs. (50.8±2.5)%, P=0.001]. The serum IL-6 concentration was negatively correlated with n-3 PUFA, n-6 PUFA, and total PUFA (r=-0.51, P<0.01; r=-0.27, P<0.01; r=-0.38, P<0.01). Conclusions Serum PUFA in patients with metabolic syndrome is lower than in healthy people. Serum IL-6 concentration may be negatively correlated with total PUFA concentration. Key words: Metabolic syndrome; Polyunsaturated fatty acid; Interleukin-6
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