Relationship between Intake of Phylloquinone (Vitamin K1) with Blood Lipids and Biomarkers of Glucose Homeostasis in Haitian Americans and African Americans With and Without Type 2 Diabetes

Abstract

BackgroundLimited evidence suggests a beneficial role of vitamin K1 in blood lipids and glucose homeostasis; however, no study exists on the associations between phylloquinone intake with blood lipids and homeostatic model assessment (HOMA) in African Americans (AA) and Haitian Americans (HA).OBJECTIVE: To determine the relationship between dietary phylloquinone intake with blood lipids and biomarkers of glucose homeostasis in AA and HA with and without type 2 diabetes (T2D). METHODS: This cross sectional study recruited participants from community centers in South Florida. Dietary phylloquinone intake was estimated by using Willet's food frequency questionnaire. Blood lipids, glucose and insulin were measured in fasting states. HOMA‐2 was used to estimate beta cell function (HOMA2‐β), insulin sensitivity (HOMA2‐IS) and insulin resistance (HOMA2‐IR). Statistical analysis included t‐test, chi‐square and linear regression. RESULTS: 390 participants (234 without T2D and 156 with T2D) were included in the analysis. The mean age was 54 years and approximately half (53%) of the participants were female. Phylloquinone intake was associated with HDL‐cholesterol (B= 0.041, P=0.015) and triglycerides (B=‐0.001, P=0.041) in HA with T2D. Phylloquinone intake was not associated with HOMA2‐IR, HOMA2‐β, and HOMA2‐IS.CONCLUSIONFindings of this study support a potential beneficial role for phylloquinone in blood lipids among HA men and women with T2D. Funding for this research was provided through an NIH/NIDDK sponsored grant.