Abstract
Objective To investigate the relationship between insulin-like growth factor-1（IGF-1）,carotid intima-media thickness（CIMT）and macrovascular complications in type 2 diabetic patients. Methods The serum IGF-1 and CIMT levels were detected in 20 of healthy controls,20 cases of type 2 diabetes without complications and 20 cases of type 2 diabetic macroangiopathy. Results The serum IGF-1 level in type 2 diabetes was lower than that in healthy controls（P 〈 0. 05）. The serum IGF-1 level in type 2 diabetic macroangiopathy was obviously lower than that in type 2 diabetes without complications （P 〈 0. 05）. The CIMT in type 2 diabetic macroangiopathy patients significantly increased than that in healthy controls and type 2 diabetes without complications（P 〈 0. 05）. Conclusions IGF-1 and CIMT is closely correlated with type 2 diabetic macroangiopathy. Key words: Diabetes; Macroangiopathy; Carotid intima-media thickness
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