Relationship between insulin-like growth factor-1 (IGF-1) concentrations and body trait measurements and climatic factors in prepubertal goat kids.

Erkan Pehlivan

doi:10.5194/aab-62-241-2019

Abstract

This study aimed to investigate relations between insulin-like growth factor-1 (IGF-1) concentrations and some body trait measurements (body weight, withers height, rump height, body length, chest depth, chest width, chest girth and cannon bone circumference) and climatic factors in prepubertal male and female White (75 % Saanen and 25 % Kilis goat) and Angora goat kids. For this purpose, blood samples were regularly taken from the vena jugularis, and body trait measurements were regularly carried out (every 15 d for 5 months) on each kid. The IGF-1 analysis on the blood serum was performed using the enzyme immunoassay (EIA) method. Climatic values and the length of the photoperiod were obtained from the Turkish State Meteorological Service for the experimental period, and the temperature–humidity index (THI) was calculated using these values. Statistical analysis showed that the IGF-1 concentrations were higher () in female White goat kids. Furthermore, differences in IGF-1 concentrations were found () between periods and between the gender groups for both the White and the Angora goat kids. Moreover, the difference between the IGF-1 concentrations between genders was higher () in White goat kids. Additionally, positive and significant correlations were found between IGF-1 concentrations and some body trait measurements in prepubertal kids, except for in female White goat kids. In summary, it was found that there was a significant relationship between IGF-1 concentrations and growth characteristics of the goat kids. Furthermore, IGF-1 concentrations in the goat kids were significantly influenced by climatic factors such as photoperiod, temperature and the temperature–humidity index, with the release of IGF-1 increasing due to increases in the photoperiod and the environmental temperature.

Highlights

Insulin-like growth factors (IGFs) are one of the most important compounds that influence metabolism in animals
insulin-like growth factor-1 (IGF-1) concentrations in experimental kids progressively increased until Period 8 and progressively decreased until end of the experiment (Fig. 2); the differences in the IGF1 concentrations between the periods were found to be statistically significant (P < 0.05; Table 3)
Significant differences were found (P < 0.05) with respect to IGF-1 concentrations between female and male kids in White goat kids, whereas no significant differences between female and male kids were observed in Angora goat kids

Summary

Introduction

Insulin-like growth factors (IGFs) are one of the most important compounds that influence metabolism in animals. IGFs are a family of polypeptides that carry out metabolic and mitogenic activities. The most potent mitogenic IGF peptide is insulin-like growth factor-1 (IGF-1), a basic polypeptide of 70 amino acids directed by growth hormone under normal physiological conditions (Buonomo et al, 1988). The bioactivity of IGF-1 is achieved by specific insulin-like growth factor binding proteins (IGFBPs) with high affinity (Obese et al, 2008). IGF-1 plays an important role in various physiological processes such as reproduction, growth, lactation and the health of the organism (McGuire et al, 1992). IGF-1 can regulate the synthesis of whole body protein, the uptake of glucose by peripheral tissues and the regulation of lipid metabolism (Hadsell et al, 2002)

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