Abstract
Summary The synthesis of Prostaglandin E2 (PGE2) from 5,8,11,14-eicosatetraenoic acid (arachidonic acid) by bovine seminal vesicle microsomes can be inhibited by the non-steroidal anti-inflammatory agents indomethacin, naproxen, its enantiomer and aspirin. The relative inhibitory potencies are 2140 to 150 to 2 to 1. These values correlate in general with anti-inflammatory, anti-pyretic and analgesic activities of these compounds, as evaluated in a number of animal models. Since the prostaglandins have been implicated in inflammation, pyresis and pain, this positive correlation adds support to the hypothesis that amode of action of aspirin-like drugs is to inhibit the biosynthesis of prostaglandins.
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