Abstract
In vivo administration of mitomycin C (MMC) to C57BL/6J mice induced a rapid, initial suppression (24 hours post injection) of in vitro mitogenesis. This was followed by of the mitogen concentration–response curves were found for two of the three mitogens, phytohemagglutinin and concanavalin A, but not for lipopolysaccharide. By 144 hours post injection, the dose-response curves and magnitude of the responses had returned to approximately control (untreated) levels. This approach provides a model system for the functional assessment of in vivo cellular damage by MMC.
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