Relationship between immune function recovery and infectious complications in patients following living donor liver transplantation.

Abstract

The ImmuKnow (IK) assay enables the evaluation of peripheral blood CD4(+) adenosine triphosphate activity to facilitate an objective assessment of the cellular immune function in immunosuppressed patients. However, it is unclear whether the IK assay is utilized during the acute postoperative periods following living donor liver transplantation (LDLT). The IK values of 43 LDLT recipients were measured during the month following LDLT to evaluate the relationship between the measured IK values and infectious events. The IK values after LDLT were significantly increased compared with the IK values before LDLT ( P <0.01). During the month following transplantation, the rate of bacterial infection in the recipients with IK values of more than 225ng/mL was significantly lower than that in the recipients with IK values of 225ng/mL or less ( 42.1% vs 91.7%, respectively; P <0.01). The rate of severe infections among the recipients who maintained IK values of more than 150ng/mL was significantly lower than that among the recipients with IK values of 150ng/mL or less during the month following transplantation ( 3.7% vs 56.3%, respectively; P <0.01). The immune system of LDLT recipients dramatically improved following transplantation. The IK values of LDLT recipients were associated with the incidence of infectious events during the perioperative period after LDLT. Monitoring IK values was useful during both the acute and long-term postoperative periods.