Relationship between IL-10 gene -819C/T polymorphism and the risk of inflammatory bowel disease: a meta-analysis.

Haien Wu,Jianchang Shu,Jingjing Guo,Yajun He,Hekun Yin

doi:10.4314/ahs.v16i3.30

Haien Wu, Jianchang Shu + Show 3 more

Open Access

https://doi.org/10.4314/ahs.v16i3.30

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Abstract

The -819C/T polymorphism in interleukin 10 (IL-10) gene has been reported to be associated with inflammatory bowel disease (IBD), but the previous results are conflicting. The present study aimed at investigating the association between this polymorphism and risk of IBD using a meta-analysis.PubMed, Web of Science,EMBASE,google scholar and China National Knowledge Infrastructure (CNKI) databases were systematically searched to identify relevant publications from their inception to April 2016.Pooled odds ratio (OR) with 95% confidence interval (CI) was calculated using fixed- or random-effects models. A total of 7 case-control studies containing 1890 patients and 2929 controls were enrolled into this meta-analysis, and our results showed no association between IL-10 gene -819C/T polymorphism and IBD risk(TT vs. CC:OR=0.81,95%CI 0.64-1.04;CT vs. CC:OR=0.92,95%CI 0.81-1.05; Dominant model: OR=0.90,95%CI 0.80-1.02; Recessive model: OR=0.84,95%CI 0.66-1.06). In a subgroup analysis by nationality, the -819C/T polymorphism was not associated with IBD in both Asians and Caucasians. In the subgroup analysis stratified by IBD type, significant association was found in Crohn's disease(CD)(CT vs. CC:OR=0.68,95%CI 0.48-0.97). In summary, the present meta-analysis suggests that the IL-10 gene -819C/T polymorphism may be associated with CD risk.

Highlights

A recent report revealed that the incidence and prevalence of inflammatory bowel disease (IBD), clinically classified into ulcerative colitis (UC) and Crohn’s disease (CD), is increasing with time and in different regions around the world, indicating its emergence as a global disease[1]
In this meta-analysis, there were six CD studies and three UC studies investigating the correlation with the interleukin 10 (IL-10) gene -819C/T polymorphism
When the results were stratified according to ethnicity, the -819C/T polymorphism was not associated with IBD in either Asians or Caucasians (Table 2).In the subgroup analysis stratified by IBD type,a significant association was found in CD(CT vs. CC:odds ratio (OR)=0.68,95%confidence interval (CI) 0.48-0.97)

Summary

Introduction

A recent report revealed that the incidence and prevalence of inflammatory bowel disease (IBD), clinically classified into ulcerative colitis (UC) and Crohn’s disease (CD), is increasing with time and in different regions around the world, indicating its emergence as a global disease[1]. The -819C/T polymorphism in interleukin 10 (IL-10) gene has been reported to be associated with inflammatory bowel disease (IBD) ,but the previous results are conflicting. Results: A total of 7 case-control studies containing 1890 patients and 2929 controls were enrolled into this meta-analysis, and our results showed no association between IL-10 gene -819C/T polymorphism and IBD risk(TT vs CC:OR=0.81,95%CI 0.641.04;CT vs CC:OR=0.92,95%CI 0.81-1.05; Dominant model: OR=0.90,95%CI 0.80-1.02; Recessive model: OR=0.84,95%CI 0.66-1.06). Conclusion: In summary, the present meta-analysis suggests that the IL-10 gene -819C/T polymorphism may be associated with CD risk. Relationship between IL-10 gene -819C/T polymorphism and the risk of inflammatory bowel disease: a meta-analysis.

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