Relationship between hypertriglyceridemic-waist phenotype and clustering of cardiovascular risk factors in adolescents

Abstract

Objective The aim of the study was to explore the relationship between hypertriglyceridemic-waist(HTWC)phenotype and clustering of cardiovascular risk factors in adolescents. Methods A cross-sectional study was conducted in 3 136 Han adolescents aged 13-17 years in Qinhuangdao. The HTWC phenotype was defined as serum triglyceride concentrations ≥1.47 mmol/L and waist circumference ≥90 th percentile for age and sex. Results The prevalence of HTWC phenotype was 3.3%. The prevalence of clustering of cardiovascular risk factors was 0.4% in adolescents with normal waist circumference and serum triglyceride and 14.7% in adolescents with HTWC phenotype. After adjustment for sex, age, body mass index, and family history of diabetes and hypertension, the prevalence of clustering of cardiovascular risk factors in adolescents with HTWC phenotype was 9.286 fold(95%CI 3.161-27.282, P<0.01)of that in adolescents with normal waist circumference and triglyceride. Conclusion There was a significant correlation between HTWC phenotype and clustering of cardiovascular risk factors, suggesting that this phenotype may be applied as a simple marker for identifying adolescents with clustering of cardiovascular risk factors. (Chin J Endocrinol Metab, 2015, 31: 95-98) Key words: Hypertriglyceridema; Waist circumference; Risk factors; Adolescents