Relationship between hypertension, obstructive sleep apnea and circadian pattern of urine sodium excretion

Abstract

wave velocities (PWVs) and impedance cardiography (BioZ) to confirm systemic hemodynamics (cardiac stroke volume/output). Results: Ages were 62 and 25 years respectively, heights 158 and 154 cm, weights 71 and 47 kg, last office BP values 119/73 and 127/80 mmHg. Mean respective 24-hour values were: BP 111/59 and 111/68 mmHg with normal nocturnal dipping patterns, heart rates 69 and 86 beats/min, cardiac outputs 4.6 and 4.3 L/min, central systolic BPs 98 and 103 mmHg, and augmentation indexes 135 and 120% (all well within 95% confidence bands). All regional PWV values were at or below the mean and median for age-adjusted or systolic BP-adjusted values. Conclusions: These findings have potential clinical and scientific implications: chronic amiloride monotherapy maintains normal office and 24-hour BP homeostasis and systemic hemodynamics in GRA, with no evidence of accelerated age-related arterial stiffening. They further suggest that either (a) hyperaldosteronism per se does not cause enhanced vascular fibrosis in humans or (b) amiloride blocks a putative pro-fibrotic effect of Aldo by an unknown mechanism.