Relationship between Histone Deacetylase (HDAC) Overexpression and 18F-FDG PET/CT Parameters in Patients with Gastric Cancer, and Prognostic Importance of HDAC Overexpression

Abstract

Ozge Ulas BABACAN1, Zekiye HASBEK2, Mukaddes YILMAZ3, Hatice OZER4, Hilmi ATASEVEN5 1Bitlis State Hospital, Department of Nuclear Medicine, Bitlis 2Cumhuriyet University Faculty of Medicine, Department of Nuclear Medicine 3Cumhuriyet University Faculty of Medicine, Department of Oncology 4Cumhuriyet University Faculty of Medicine, Department of Pathology 5Cumhuriyet University Faculty of Medicine, Department of Gastroenterology Keywords: HDAC, HDACI, 18F-FDG PET/CT, Gastric cancer Histon Deacetylases (HDACs) exert a pro-oncogenic effect by keeping genes that cause differentiation, apoptosis, and cell cycle arrest in a transcriptionally quiescent state. Moreover to achieve our aim, we investigated the relationship between the patients’ HDAC protein expression rates and their prognosis. In no patients, tumors were located in the cardia and corpus. While the median HDAC1 protein score was 3.5 in the early stage patients, it was 8 in the advanced stage (stage 1-2) patients, and 12 in the metastatic stage (stage 4) patients. There was a significant correlation between HDAC protein positivity and tumor localization (p= 0.030). Significant correlation was observed between histopathological stages and median HDAC1 protein scores. (p= 0.021). The HDAC1 protein score increased as the patients’ stage progressed. Given the relationship between HDAC1 proteins and the survival of the patients, the 2-year survival rate was high in HDAC1 positive patients; however, it was not statistically significant. According to the results of our study, in HDAC1-positive gastric cancer patients, there was no significant relationship between SUVmax showing tumor metabolism in 18F-FDG PET/CT.