Abstract
The hippocampus has been implicated in the emotional responses of sympathetic nerve activity (SNA) to fear. However, there is a lack of direct evidence of the changes in hippocampal neuronal activity and SNA and on the functional relationships between these activities during the fear response. The aim of the present study was to measure the relationship between hippocampal neuronal activity and SNA during fear conditioning. Male Wistar rats were chronically implanted with multiple electrodes to monitor hippocampal CA1 neuronal activity, and bipolar electrodes to monitor renal SNA (RSNA) and lumbar SNA (LSNA). Electroencephalography was performed. Each rat was given a 5‐s tone terminating with a 1‐s, 5‐mA foot shock twice a day over 3 days. Hippocampal CA1 neuronal activity, RSNA, and LSNA were measured simultaneously during the quiet awake state in the rat's own cage. Heart rate decreased during the 3‐day fear conditioning. Hippocampal CA1 neuronal activity and RSNA increased, while LSNA decreased during the 3‐day fear conditioning. These data suggest that there is a positive neuronal coupling between hippocampal neural activity and RSNA during fear conditioning in rats. JSPS Grant.
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