Relationship between high-risk human papillomavirus viral load and clinical pathological factors of cervical cancer

Abstract

Objective To study the relationship between high-risk human papillomavirus (HR-HPV) viral load and clinical pathological factors of cervical cancer. Methods Ninety-seven initial treatment patients with cervical cancer were selected, and they were diagnosed by pathological examination. The relationship was analyzed between HR-HPV viral load and clinical pathological factors of cervical cancer. Results The HR-HPV viral load in cervical cancer Ⅰ stage (45 cases) was significantly higher than that in cervical cancer Ⅱ stage (29 cases) and cervical cancer ≥Ⅲ stage (23 cases): 484.03 (289.22, 773.54) RLU/CO vs. 88.24 (53.15, 133.30) and 41.41 (13.39, 164.21) RLU/CO, and there was statistical difference (P 0.05). The HR-HPV viral load in cervical cancer 100 RLU/CO group (57 cases) and ≤100 RLU/CO group (40 cases) according to the HR-HPV viral load. The rate of cervical cancer ≥Ⅱ B stage in ≤100 RLU/CO group was significantly higher than that in >100 RLU/CO group: 75.0% (30/40) vs. 33.3% (19/57), and there was statistical difference (P <0.01). Among 97 patients with cervical cancer, well-differentiated was in 9 cases, moderately differentiated in 58 cases, poorly differentiated in 19 cases, and the degree of differentiation was not clear in 11 cases. The HR-HPV viral load in well and moderately differentiated patients was significantly higher than that in poorly differentiated patients: 173.56 (62.76, 523.92) RLU/CO vs. 45.71 (4.05, 164.21) RLU/CO, and there was statistical difference (P <0.05). Conclusions The HR-HPV viral load is decreased with the progression of cervical cancer clinical staging and pathological grading. It shows that HR-HPV viral load in the progression of cervical cancer is not obvious. Lower HR-HPV viral load is common in cervical cancer ≥ⅡB stage. It may indicate that low viral load is one of the indicators of poor prognosis in patients with cervical cancer. Key words: Uterine cervical neoplasms; Viral load; Papillomavirus infections