Abstract
This study aimed to explore the spectrum-effect relationships between high-performance liquid chromatography fingerprints and the uric acid-lowering activities of chicory. Chemical fingerprints of chicory samples from ten different sources were determined by high-performance liquid chromatography, and then investigated by similarity analysis and hierarchical clustering analysis. Pharmacodynamics experiments were conducted in animals to obtain the uric acid-lowering activity information of each chicory sample. The spectrum-effect relationships between chemical fingerprints and the uric acid-lowering activities of chicory were established by canonical correlation analysis. The structures of potential effective peaks were identified by liquid chromatography with tandem mass spectrometry. The results showed that a close correlation existed between the spectrum and effect of chicory. Aesculin, chlorogenic acid, chicoric acid, isochlorogenic acid A/B/C and 13,14-seco-stigma5(6),14(15)-diene-3α-ol might be the main effective constituents. This work provides a general model of the combination of high-performance liquid chromatography and uric acid-lowering activities to study the spectrum-effect relationships of chicory, which can be used to discover the principle components responsible for the bioactivity.
Highlights
Cichorium intybus L., commonly known as chicory, is a perennial herb of the Asteraceae family
The statistical serum Uric acid (UA) level results suggested that the model group had a significant higher level compared with control group (p < 0.05), which indicated that the hyperuricemia model was built successfully
The results showed that aesculin, chlorogenic acid, chicoric acid, isochlorogenic acid A/B/C and
Summary
Cichorium intybus L., commonly known as chicory, is a perennial herb of the Asteraceae family. Chicory contains a number of medicinally important phytoconstituents, mainly belonging to the alkaloid, phenolic acid, sesquiterpene lactone, aliphatic compounds and their derivatives, volatile oil, flavonoid, and polysaccharide classes, etc. Chicory was grown by the ancient Egyptians as a medicinal plant, vegetable, and forage plant, etc. According to the FDA, chicory extract fits the category of “generally regarded as safe” (GRAS) and appears in the list of Everything Added to Food in the United States (EAFUS) [8]. Some studies have proved the health benefits of chicory when used as a food or medicinal plant [9]. In India, the whorls are made into a decoction and used for the treatment of liver disorders, gout and rheumatism [6]
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