Relationship Between High-Density Lipoprotein Cholesterol and Mortality in Elderly Hemodialysis Patients: Data From the Korean Society of Geriatric Nephrology Retrospective Cohort

Seung Hye Chu,Eun Hee Park,Haekyung Lee,Yu Ah Hong,Woo Yeong Park,Jang-Hee Cho,In O Sun,Won Min Hwang,Soon Hyo Kwon,Jin Seok Jeon,Hyunjin Noh,Kyung Don Yoo,Hyoungnae Kim

doi:10.1053/j.jrn.2024.05.003

Abstract

BackgroundThe association between high-density lipoprotein (HDL) cholesterol levels and mortality in elderly patients undergoing hemodialysis is not well established. Thus, this study investigated HDL levels and mortality in elderly Korean patients undergoing hemodialysis. MethodsWe recruited 1860 incident hemodialysis patients aged > 70 years from a retrospective cohort of the Korean Society of Geriatric Nephrology. The primary outcome measure was the all-cause mortality. ResultsThe mean age of the cohort was 77.8 years and 1049 (56.4%) were men. When we grouped the patients into HDL cholesterol tertiles, the T1 group (HDL level <30 mg/dL in men and <33 mg/dL in women) had a higher proportion of patients with end-stage kidney disease due to diabetic nephropathy. During the median follow-up period of 3.1 years, 1109 (59.7%) deaths occurred. In a multivariable Cox regression model, the T1 group had significantly higher risk of mortality (hazard ratio [HR], 1.28; 95% confidence interval [CI], 1.10-1.50; p=0.002) compared to the T3 group. A nonlinear analysis using a restrictive spline curve showed that low HDL cholesterol levels were associated with increased HR when HDL cholesterol levels were < 40 mg/dL; however, there was no association between HDL cholesterol and mortality when HDL cholesterol levels were > 40 mg/dL. Triglyceride/HDL ratio was not significantly associated with risk of mortality (HR per 1 log increase, 1.08; 95% CI, 0.99-1.18; p=0.069). ConclusionsLow HDL cholesterol levels are associated with an increased risk of mortality in elderly patients undergoing hemodialysis. However, there was no significant relationship between HDL cholesterol levels and mortality when levels were below 40 mg/dL. Therefore, low HDL cholesterol levels may be a useful risk factor for predicting mortality in elderly patients undergoing hemodialysis.

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