Relationship between high sensitive C-reactive protein and stroke subtype according to Chinese Ischemic Stroke Subclassification criteria in patients with acute cerebral infarction

Abstract

By analyzing the clinical data of 216 cases of acute cerebral infarction (ACI) from 2012 January to 2013 June retrospectively, we found that the serum levels of high sensitive C-reactive protein (hs-CRP) in patients were significantly higher than those in 186 controls (P 8 were higher than that in those with NIHSS score ≤8 (P<0.05). The hs-CRP level of patients of large artery atherosclerosis were (6.32±4.12) mg/L and the positive rate of hs-CRP was 85.7%(84/98). All were respectively higher than those in patients of penetrating artery disease [(1.97±0.86) mg/L, 7/71], cardiogenic stroke [(3.70±2.76) mg/L, 14/24], undetermined etiology [(3.43±3.52) mg/L, 5/11] and other etiologies [(3.41±3.25) mg/L, 5/12] (all P<0.05). Logistic regression analysis was performed for the risk factors of ACI. The correlative factors of ACI included hypertension, diabetes mellitus, atrial fibrillation, smoking, total cholesterol, homocysteine and high sensitive C-reactive protein (OR=1.56, 1.19, 1.23, 1.17, 3.08, 1.34, 1.25, all P<0.01). The serum levels of hs-CRP increased significantly in ACI patients and were correlated with the degree of neural function defect. Key words: Cerebral infarction; C-reactive protein; Homocysteine; Chinese Ischemic Stroke subclassification