Abstract
Objectives The objective of this study was to evaluate the association of Helicobacter pylori stool antigen (HPSA) with pre-eclampsia (PE) complicated by intrauterine growth restriction (IUGR). Background PE is a severe hypertensive pregnancy-related disorder that affects 5-8% of women worldwide, thus representing the main cause of fetomaternal mortality and morbidity; it is often associated with fetal growth restriction (IUGR), which is defined as failure of the fetus to achieve its genetically determined growth potential. Materials and methods This is a prospective study for 100 pregnant women divided into two groups: 50 pregnant women with a diagnosis of PE with IUGR and 50 women with uneventful pregnancies (control); maternal stool samples were collected from all patients between 34 and 38 weeks of gestation, and HPSA was measured using monoclonal antibody test, which is an immunochromatographic assay that uses antibody-coated colloidal gold. Results A significantly higher percentage of women who were positive for HPSA were found among PE cases complicated by IUGR (76%) compared with uneventful pregnancies (32%) (P < 0.001). Conclusion HPSA has a direct role in the etiopathogenesis of PE complicated by IUGR.
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